Why do we sleep? What science knows and doesn't

Sleep is essential, but its core purpose is still unresolved. Several theories, likely overlapping, point to energy saving, bodily and brain restoration, and brain plasticity.

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The short answer

Nobody has a single agreed answer. The National Institute of Neurological Disorders and Stroke says everyone needs sleep but its biological purpose remains a mystery, even though sleep affects almost every tissue and system in the body. Harvard's sleep medicine education program says that, after decades of research, the question has been hard to answer, and that no single theory is likely to be proven correct. Sleep is more likely explained by two or more theories combined. [1] [2]

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What we do know sleep does

Without sleep, the brain struggles to form and maintain the pathways that support learning and new memories, and concentration and reaction speed suffer. The brain and body stay quite active during sleep. Chronic lack of sleep or poor sleep is linked to higher risk of high blood pressure, cardiovascular disease, diabetes, depression and obesity. [1]

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The main theories

The inactivity (or adaptive) theory holds that staying still at night kept animals out of harm's way, and natural selection turned this into sleep. A counter-argument is that staying awake and conscious would be safer still, so unconsciousness is not explained by safety alone. [2]

The energy conservation theory says sleep lowers energy demand when searching for food is least efficient. Metabolism falls by as much as 10 percent in humans during sleep, and by more in other species, and body temperature and calorie demand drop. Many scientists regard this as related to, and part of, the inactivity theory. A Stanford sleep researcher, Jamie Zeitzer, also lists energy saving among many things happening during sleep, which he says enhances wakefulness. [2] [3]

Restorative theories say sleep repairs what wakefulness wears down. Animals deprived entirely of sleep lose immune function and die within weeks, and muscle growth, tissue repair, protein synthesis and growth hormone release occur mostly or only during sleep. Adenosine, a by-product of neural activity, builds up while awake and is thought to drive sleepiness; it is cleared during sleep. Animal studies also describe the glymphatic system, a brain drainage pathway that works more efficiently in sleep and clears substances such as beta amyloid. [2]

Two newer ideas concern the brain's wiring. Synaptic homeostasis proposes that daytime activity adds synapses, and sleep prunes unneeded ones and strengthens essential ones, with animal studies showing synapses shrinking and expanding across sleep and wakefulness. Brain plasticity theory links sleep to changes in brain structure and organization. It is tied to brain development, since infants sleep about 13 to 14 hours a day, about half in REM sleep, and to learning in adults. Harvard describes all these theories as unproven. [2]

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Why the question is hard

Researchers have studied sleep deprivation in humans and animals and compared sleep patterns across species, looking for clues to its function. Harvard compares sleep to eating: both are driven by powerful internal urges, hunger or sleepiness, that are relieved by meeting the need. Unlike eating, though, sleep does not involve taking in a substance, so its benefit is harder to pin down. Popular summaries describe it as a mix of memory storage, waste clearance, cell repair and energy restoration, which fits the idea that sleep serves several functions at once. [2] [4]

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Sources

  1. Brain Basics: Understanding Sleep | National Institute of Neurological Disorders and Stroke (ninds.nih.gov) Found by source search. Not checked by a person.
  2. Why Sleep Matters: Benefits of Sleep | Sleep Medicine (sleep.hms.harvard.edu) Found by source search. Not checked by a person.
  3. The science of better sleep with Jamie Zeitzer | Health Compass Podcast | Stanford Medicine | Stanford Medicine (med.stanford.edu) Found by source search. Not checked by a person.
  4. Why Do We Sleep? What Happens During Sleep? (healthline.com) Found by source search. Not checked by a person.

Questions to follow next

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